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Meningioma
From Wikipedia, the free encyclopedia
| Meningioma Classification and external resources | |
 | |
|---|---|
| A contrast enhanced CT scan of the brain, demonstrating the appearance of a Meningioma. | |
| ICD-10 | C70, D32 |
| ICD-9 | 225.2 |
| ICD-O: | 9530 |
| OMIM | 607174 |
| DiseasesDB | 8008 |
| eMedicine | neuro/209 radio/439 |
| MeSH | D008579 |
Meningiomas are the most common primary tumor of the central nervous system, arising from the arachnoid "cap" cells of the arachnoid villi in the meninges.[1] These tumours are usually benign in nature; however, they can be malignant.[2]
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Causes
Most cases are sporadic while some are familial. Persons who have undergone radiation to the scalp are more at risk for developing meningiomas.[3]
The most frequent genetic mutations involved in meningiomas are inactivation mutations in the neurofibromatosis 2 gene (merlin) on chromosome 22q. Other possible genes/loci include: MN1[4] PTEN[5] an unknown gene at 1p13[6]
